Biochemistry 158/258

Oocyte niche

Genomics, Bioinformatics & Medicine

Stem Cells

Doug Brutlag


Lecture Resources

Stem Cell Slides

Stem Cell Lecture Video


Recent Stem Cell Literature

Additional Literature References

Reprogramming of human somatic cells to pluripotency with defined factors Park et al, (2008) Nature 451, January 10, pp 141- 147.

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Takahashi et al. (2007) Cell 131, 861-872.

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells Yu et al, (2007) Science 318, 1917.

Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells Yamanaka, REVIEW (2007) Cell Stem Cell 1. July 2007 pp 39- 49.

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells Lujan et al. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2527-32.

Stem Cell Niche: Structure and Function. Li and Xie (2005) Annual Review of Developmental Biologyh 21, p 606-663.

Stem Cell Therapeutics. Singrec et al. 2008 Stem Cells Vol 1 pp. 313-328.

Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Sun N, et al. (2009) Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15720-5.

Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Fan et al. (2008) PNAS 105, 16266-16271

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Soldner et al. (2009). Cell. 2009 Mar 6;136(5):964-77.

Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Kim et al. (2009) Cell Stem Cell. 2009 Jun 5;4(6):472-6.

The immortal strand hypothesis: segregation and reconstruction. Rando, TA (2007) Cell. 2007 Jun 29;129(7):1239-43

High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. Conboy, MJ, Karasov, AO, Rando, TA. (2007) PLoS Biol. 2007 May;5(5):e102.

Mutation selection and the natural history of cancer. Cairns, J. (1975) Nature. 1975 May 15;255(5505):197-200.

Intraflagellar Transport Rosenbaum, J. L. and Wittman G. B. (2002) Nat Rev Mol Cell Biol. 2002 Nov;3(11):813-25.

Lectures Available to Stanford Students only.

Henry Stewart Talks

Stem cells from the early embryo (39 mins)  Prof. Janet Rossant  –  Hospital for Sick Children, University of Toronto, Ontario, Canada

Gene expression analysis of pluripotent stem cells (25 mins)  Dr. Uma Lakshmipathy  –  Life Technologies, USA

Stem cells derived from amniotic fluid and placenta (30 mins)  Prof. Anthony Atala  –  Wake Forest Institute for Regenerative Medicine, USA

Hematopoietic stem cells and progenitor cells: their role in normal blood formation   Prof. Malcolm Moore  –  Memorial Sloan Kettering Cancer Center, USA

Stem and progenitor cells from peripheral blood (45 mins)  Prof. Shay Soker  –  Wake Forest Institute for Regenerative Medicine, USA

Stem cells from adipose tissue (40 mins)  Dr. Adam J. Katz  –  University of Florida, USA